Resveratrol Keeps You Young
http://healthfieldmedicare.suite101.com/article.cfm/keep-me-young-how-resveratrols-pulling-it-off
Supplements claiming to help people stay young and healthy as long as possible has browsers scouring the internet day after day for the latest research, sifting out what’s believable and what’s not: and for good reason. Studies show that in the next two decades the number of Americans 65 years of age and up will grow from 35 million to 71 million. It's no surprise that scientists, researchers, and even those thirty-somethings noticing their first wrinkle, are searching for an intervention. And in the form of a measly grape-skin, that intervention has finally arrived.
Dr. Joseph Maroon, a neurosurgeon who doubles as a triathlete, father, and author, is a fairly well-known contributor to age-related and epidemiological research. As the team neurosurgeon for the NFL Pittsburg Steelers, he began studying nutritional factors that would improve health and prevent disease. In so doing, he became fascinated with the now widely renowned molecule resveratrol, and its ability to activate what is called the SIRT1 longevity gene.
SIRT1 and Longevity
Found in red grapes and the vines on which they grow, resveratrol has been most often associated with activating the longevity gene, sirtuin 1 (SIRT1). According to research done by Mitchell Knutson and Christiaan Leeuwenburgh, professors in food science and the biology of aging at the University of Florida, SIRT1 increases energy efficiency of cells in the body. The SIRT1 gene needs to be continually reactivated over to increase cellular energy, which means continued ingestion of resveratrol is necessary to continue seeing the benefits.
Obesity
The goal of Dr. Maroon’s research was not only to find a way to live longer, but healthier as well. Studies done by Joseph A. Baur of the University of Pennsylvania School of Medicine show that mice fed a high fat diet, who were more likely to develop diabetes and a decreased lifespan, lived longer with 22.4mg of resveratrol a day. To get an idea of how feasible this dose is in humans, it takes 20mg of resveratrol to activate the SIRT1 gene, and there’s only .25mg in your average glass of wine. The result of the study found that though the mice became increasingly obese on their high fat diet, the ones on resveratrol lived longer and healthier overall.
Alzheimer’s
In addition, resveratrol also has therapeutic potential in Alzheimer’s disease, an age-related, neurodegenerative disorder that distorts memory. Alzheimer’s disease comes from intracellular degradation in the brain. The most common cause of Alzheimer’s is the build up of a protein fragment between nerve cells called beta-amyloid (Aβ).
What the Litwin-Zucker research Center for the Study of Alzheimer’s Disease found was that resveratrol markedly lowered the levels of secretion of the amyloid-β peptide. It doesn’t completely put a stop to its production, but degrades the intracellular structure of Aβ by way of the proteasome, a destroyer of unneeded proteins. In short, resveratrol lowers the level of amyloid peptide build up within cells, which has the potential to significantly decrease the onset of Alzheimer’s.
With over 250 scientific papers published along with 8 books, Dr. Joseph Maroon currently backs the resveratrol supplement Resvitale. His most recent book entitledThe Longevity Factor: How Resveratrol and Red Wine can Activate Genes for a Longerand Healthier Life explores in greater depth the effect supplements have on our genes, and how we can better prepare our bodies to prevent the ravages of old age.
References:
Knutson, D. Michael, Leeuwenburgh, Christiaan. "Resveratrol and novel potent activators of SIRT1: Effects on Aging and Age-related Diseases". Nutrition Reviews Vol. 66(10):591-596. Print.
Marambaud, Philippe, Zhao Haitian, Davies, Peter. "Resveratrol Promotes Clearance of Alzheimer's Disease Amyloid-β Peptides". Journal of Biological Chemistry Vol 280(45): 37377-82. Print.
© 2010 Monique Muro
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http://jama.ama-assn.org/cgi/content/abstract/303/23/2377
JAMA. 2010;303(23):2377-2385.
Context B vitamins and factors related to 1-carbon metabolism help to maintain DNA integrity and regulate gene expression and may affect cancer risk.
Objective To investigate if 1-carbon metabolism factors are associated with onset of lung cancer.
Design, Setting, and Participants The European Prospective Investigation into Cancer and Nutrition (EPIC) recruited 519 978 participants from 10 countries between 1992 and 2000, of whom 385 747 donated blood. By 2006, 899 lung cancer cases were identified and 1770 control participants were individually matched by country, sex, date of birth, and date of blood collection. Serum levels were measured for 6 factors of 1-carbon metabolism and cotinine.
Main Outcome Measure Odds ratios (ORs) of lung cancer by serum levels of 4 B vitamins (B2, B6, folate [B9], and B12), methionine, and homocysteine.
Results Within the entire EPIC cohort, the age-standardized incidence rates of lung cancer (standardized to the world population, aged 35-79 years) were 6.6, 44.9, and 156.1 per 100 000 person-years among never, former, and current smokers for men, respectively. The corresponding incidence rates for women were 7.1, 23.9, and 100.9 per 100 000 person-years, respectively. After accounting for smoking, a lower risk for lung cancer was seen for elevated serum levels of B6 (fourth vs first quartile OR, 0.44; 95% confidence interval [CI], 0.33-0.60; P for trend <.000001), as well as for serum methionine (fourth vs first quartile OR, 0.52; 95% CI, 0.39-0.69; P for trend <.000001). Similar and consistent decreases in risk were observed in never, former, and current smokers, indicating that results were not due to confounding by smoking. The magnitude of risk was also constant with increasing length of follow-up, indicating that the associations were not explained by preclinical disease. A lower risk was also seen for serum folate (fourth vs first quartile OR, 0.68; 95% CI, 0.51-0.90; P for trend = .001), although this was apparent only for former and current smokers. When participants were classified by median levels of serum methionine and B6, having above-median levels of both was associated with a lower lung cancer risk overall (OR, 0.41; 95% CI, 0.31-0.54), as well as separately among never (OR, 0.36; 95% CI, 0.18-0.72), former (OR, 0.51; 95% CI, 0.34-0.76), and current smokers (OR, 0.42; 95% CI, 0.27-0.65).
Conclusion Serum levels of vitamin B6 and methionine were inversely associated with risk of lung cancer.
Author Affiliations: International Agency for Research on Cancer (IARC), Lyon, France (Drs Johansson, Slimani, Boffetta, Jenab, and Brennan); Institute for Ageing and Health, Newcastle University, Newcastle, United Kingdom (Dr Relton); Section for Pharmacology, Institute of Medicine, University of Bergen, and Laboratory of Clinical Biochemistry, Haukeland University Hospital (Dr Ueland), Bergen, Norway; Department of Public Health and Primary Health Care, University of Bergen, and Division of Epidemiology, Norwegian Institute of Public Health (Dr Vollset), Bergen, Norway; Bevital AS, Bergen, Norway (Dr Midttun); Department of Heart Disease, Haukeland University Hospital, and Section for Cardiology, Institute of Medicine, University of Bergen (Dr Nygård) Bergen, Norway; INSERM ERI20 (Institut National de la Santé et de la Recherche Médicale), ERI20, Institut Gustave Roussy, and Paris South University (Drs Clavel-Chapelon, Boutron-Ruault, and Fagherazzi), Villejuif, France; Divisions of Cancer Epidemiology (Dr Kaaks), and Clinical Epidemiology (Dr Rohrmann), German Cancer Research Centre, Heidelberg, Germany; Department of Epidemiology, German Institute of Human Nutrition, Potsdam-Rehbruecke, Nuthetal, Germany(Dr Boeing and Weikert); National Institute for Public Health and the Environment (RIVM), Bilthoven, the Netherlands (Dr Bueno-de-Mesquita and Ms Ros); Department of Epidemiology, Biostatistics and HTA, Radboud University Nijmegen Medical Centre, Nijmegen, the Netherlands (Ms Ros); Julius Center for Health Sciences and Primary Care, University Medical Center, Utrecht, the Netherlands (Drs van Gils and Peeters); Faculty of Medicine, Imperial College, London, United Kingdom (Dr Peeters); Unit of Nutrition, Environment and Cancer, Catalan Institute of Oncology (ICO-IDIBELL), Barcelona, Spain (Dr Agudo); Public Health Institute of Navarra, Pamplona, Spain (Dr Barricarte); CIBER Epidemiología y Salud Pública (CIBERESP), Barcelona, Spain (Drs Barricarte, Navarro, Sánchez, and Larrañaga); Department of Epidemiology, Regional Council of Health and Consumer Affairs, Murcia, Spain (Dr Navarro); Public Health and Participation Directorate, Health and Health Care Services Council, Asturias, Spain (Dr Rodríguez); Andalusian School of Public Health, Granada, Spain (Dr Sánchez); Public Health Division of Gipuzkoa, Basque Government, Donostia-San Sebastian, Spain (Dr Larrañaga); Department of Gerontology, Department of Public Health and Primary Care, University of Cambridge (Dr Khaw), and MRC Epidemiology Unit, Strangeways Research Laboratory (Dr Wareham) Cambridge, United Kingdom; Cancer Epidemiology Unit, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom (Drs Allen and Crowe); Division of Epidemiology, and Public Health and Primary Care, Imperial College, London, United Kingdom (Drs Gallo, Norat, Riboli, and Vineis); MRC/HPA Centre for Environment and Health, Imperial College, London, United Kingdom (Dr Vineis); Epidemiology Unit, National Cancer Institute, Milan, Italy (Dr Krogh); Molecular and Nutritional Epidemiology Unit, ISPO -Cancer Research and Prevention Institute, Florence, Italy (Dr Masala); Department of Clinical and Experimental Medicine, Federico II University, Naples, Italy (Dr Panico); Center for Cancer Prevention (CPO-Piemonte), and Human Genetic Foundation (HuGeF), Torino, Italy (Dr Sacerdote); Cancer Registry, Azienda Ospedaliera "Civile MP Arezzo," Ragusa, Italy (Dr Tumino); WHO Collaborating Center for Food and Nutrition Policies, Department of Hygiene, Epidemiology and Medical Statistics, University of Athens Medical School, Athens, Greece (Drs Trichopoulou and Lagiou); Hellenic Health Foundation, Athens, Greece (Drs Trichopoulou); Department of Epidemiology, Harvard School of Public Health, Harvard University, Boston, Massachusetts (Drs Lagiou and Trichopoulos); Bureau of Epidemiologic Research, Academy of Athens, Athens, Greece (Dr Trichopoulos); Departments of Radiation Sciences, Oncology (Dr Rasmuson), Public Health and Clinical Medicine, Nutritional Research (Dr Hallmans), and Nutritional Research (Dr Vineis), Umeå University, Umeå, Sweden; MRC/HPA Centre for Environment and Health, Imperial College, London, United Kingdom, and ISI Foundation, Torino, Italy (Dr Vineis).
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A weekend feast can easily ruin all the progress that you’ve made watching your diet throughout the week.
But the May issue of Fitness Magazine may just help you to stay on track and avoid cravings.
The CBS lists these tips as under:
Friday
"At happy hour: Alcohol makes you hungry because it lowers your blood sugar, as well as lowering your inhibitions about what you’ll eat. Consider ordering a different drink than you normally would – you’re more likely to order a second round when it’s your favorite drink. Also, avoid getting a pitcher of sangria or margaritas, when you can lose sight of how much you’re drinking if someone is constantly topping off your glass."
"Dinner out: Research shows that women eat similarly when they are together - so you’ll consume less if you try to sit next to light eaters. To avoid being swayed by someone’s order, try to order first and make a healthy choice up front."
Saturday
"Doing chores: When you’re at home and close to the kitchen, eating is a way to fend off boredom and procrastinate. Instead of grazing, make yourself a mini meal - and then take it to another room. Having to walk back to the kitchen will help prevent mindlessly eating."
"At a dinner party: Dinner parties can be challenging for dieters because you don’t have control of the menu and can offend your hosts if you don’t eat. Try to fill up your plate with leafy greens, and if your host is insistent about seconds, suggest taking some home with you instead."
Sunday
"Sunday brunch: A leisurely brunch is filled with rich menu options. Consider sharing a treat with the table to satisfy cravings and order a nutritious entrée. If the group lingers at the table, have your plate removed - ordering more coffee increasing your chances of grazing."
"Sunday night: If you’ve slipped on your diet this weekend, you may feel like throwing in the towel. To increase the chances you’ll keep things under control, try a portioned snack like a piece of dark chocolate or a low-fat ice cream sandwich. Also consider going to bed early - sometimes people eat in response to exhaustion."
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Vitamin E shows promise for treating liver disease
LOS ANGELES — People with a common, obesity-related liver disease that has no known treatment got a surprising benefit from vitamin E pills, researchers reported Wednesday.
It appears to be the first time that a vitamin supplement has been shown to help treat a major ailment not caused by a nutrient deficiency. However, doctors warned that this does not mean people should automatically take vitamin E since some research suggests it might raise the risk of other problems.
The latest study tested it for nonalcoholic fatty liver disease. Fat buildup can cause the liver to become inflamed and scarred over time and in severe cases, to fail.
The disease usually develops in people who are middle-aged and overweight or obese. Up to 5 percent of Americans have the most serious form of it, and as many as 20 percent have fat in their livers but no organ damage.
In the study published online in the New England Journal of Medicine, 247 adults with advanced fatty liver disease were randomly assigned to take a high dose of vitamin E (800 international units), the diabetes drug Actos or dummy pills for nearly two years.
The vitamin and drug were tested because earlier research suggested liver cell deterioration and insulin resistance might be involved in the development of the disease.
Biopsies before and after treatment showed that liver function improved in 43 percent of those in the vitamin E group compared with 19 percent in the placebo group.
"In all honesty, I was surprised," said the lead researcher, Dr. Arun Sanyal of Virginia Commonwealth University. "A vitamin has not been previously used to cure a serious disease" that is not caused by a deficiency.
Vitamin deficiency has been blamed for a range of health problems from rickets and osteoporosis from a lack of vitamin D to scurvy from not enough vitamin C.
Study participants on the diabetes drug Actos also improved, but to a lesser degree and with a drawback: gaining 10 pounds on average, which remained even after they stopped taking the drug. Four people who took vitamin E developed diabetes, but the study was too small to determine if the vitamin played any role.
The National Institutes of Health was the study's main sponsor. A U.S. subsidiary of Japan-based Takeda Pharmaceutical provided the drug and California-based supplement maker Pharmavite supplied the vitamin E capsules. Sanyal, the lead researcher, has received consulting fees from Takeda and other drug companies.
Liver expert Dr. Sammy Saab at the University of California, Los Angeles, believes vitamin E could potentially become the initial treatment for advanced cases of the liver problem.
"For patients who are really at risk of progressive liver disease, I think it's worthwhile. For the vast majority who just have fatty liver, I'm not sure it will help them at all," said Saab, who had no role in the study.
Dr. Zobair Younossi, executive director of research at the nonprofit Inova Health System in Virginia, said people with nonalcoholic fatty liver disease at the very least should make lifestyle changes such as eating a healthy diet and exercising to shed the pounds.
While vitamin E may help certain people with obesity-related liver disease, "I wouldn't get started on high-dose vitamin E without discussing it first with a doctor," said Younossi, who has no connection to the research.
In recent years, hype over vitamin supplements in treating major diseases has not panned out. A 2008 study found that vitamins C and E pills do not ward off heart disease in men and vitamin E even appeared to raise the risk of bleeding strokes. Another study found the same supplements do not help prevent cancer in men.
On the Net: New England Journal of Medicine: http://www.nejm.org
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The study found that men who consumed an egg-based breakfast ate significantly fewer calories when offered an unlimited lunch buffet compared to when they ate a carbohydrate-rich bagel breakfast of equal calories.
The study supports previous research which revealed that eating eggs for breakfast as part of a reduced-calorie diet helped overweight dieters lose 65 percent more weight and feel more energetic than dieters who ate a bagel breakfast of equal calories and volume.
“There is a growing body of evidence that supports the importance of high-quality protein in the diet for overall health and in particular the importance of protein at the breakfast meal. We examined two typical American breakfasts, and the participants’ self-reported appetite ratings reveal that a protein-rich breakfast helps keep hunger at bay,” said Dr. Maria Luz Fernandez., study author and professor in the department of nutritional sciences at the
“Starting the day with a high-quality protein breakfast like eggs is a great tool to promote long-lasting fullness and reducedcalorie consumption. For only 70 calories, eggs are a compact, nutrient-rich source of high-quality protein, and nearly half of an egg’s protein, along with many other nutrients, is found in the yolk, so I always encourage eating the whole egg,” said Helenbeth Reynolds, registered dietitian and nutrition consultant.
The study has been published in the latest issue of Nutrition Research. (ANI)
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ANAHEIM, CA, April 27, 2010 -- There's more evidence of tart cherries' powerful anti-inflammatory benefits, according to a new study presented by a team of Michigan researchers today at the Experimental Biology annual meeting. Using a "whole food" approach, researchers found that a cherry-enriched diet not only reduced overall body inflammation, but also reduced inflammation at key sites (belly fat, heart) known to affect heart disease risk in obese, at-risk rats.
At-risk obese rats were fed a cherry-enriched "Western Diet," characterized by high fat and moderate carbohydrate -- in line with the typical American diet -- for 90 days. Cherry-enriched diets, which consisted of whole tart cherry powder as 1 percent of the diet, reduced risk factors for heart disease including cholesterol, body weight, fat mass and known markers of inflammation. While inflammation is a normal process the body uses to fight off infection or injury, according to recent science, a chronic state of inflammation increases the risk for diseases.
"Chronic inflammation is a whole body condition that can affect overall health, especially when it comes to the heart," said study co-author Mitch Seymour, PhD, at the University of Michigan. "This study offers further promise that foods rich in antioxidants, such as cherries, could potentially reduce inflammation and have the potential to lower disease risk."
A second pilot study found similar results in humans. Ten overweight or obese adults drank eight ounces of tart cherry juice daily for four weeks. At the end of the trial, there were significant reductions in several markers of inflammation, in addition to lower levels of triglycerides, another key risk factors for heart disease.
Researchers say both studies are encouraging and will lead to further clinical studies in humans to explore the link between diet, inflammation and lowering disease risk.
The Power of Eating Red
This new study is the latest linking cherries to protection against heart disease and inflammation. Researchers believe it's the anthocyanins powerful antioxidant compounds in cherries ? also responsible for the fruit's bright red color, that link cherries to reduced inflammation, even inflammation related to muscle recovery post-exercise.
Since cherries are available year-round in dried, frozen and juice forms, it's easy and delicious to incorporate them into the daily diet to help manage inflammation, from topping dried cherries in oatmeal to enjoying a post-exercise smoothie of cherry juice and lowfat yogurt.
The study was funded by the Cherry Marketing Institute, which provided an unrestricted grant to the University of Michigan to conduct the research and was not directly involved in the design, conduct or analysis of the project. For more information, and to download the Cherry Nutrition Report, a compilation of more than 65 published studies on the potential health benefits of cherries, visit www.choosecherries.com.
Sources:
Seymour EM, Urcuyo-Llanes D, Bolling SF, Bennink MR. Tart cherry intake reduces plasma and tissue inflammation in obesity-prone rats. FASEB Journal. 2010; 24:335.1.
Martin KR, Burrell L. 100% tart cherry juice reduces pro-inflammatory biomarkers in overweight and obese subjects. FASEB Journal. 2010; 24:724.15.
Martin KR, Bopp J, Neupane S, Vega-Lopez. 100% tart cherry juice reduces plasma triglycerides and CVD risk in overweight and obese subjects. FASEB Journal. 2010; 24:722.14.
Editor's Note: Co-author E. Mitchell Seymour is available for interviews upon request. To coordinate a time to speak with the researcher, please contact Caitlin Solway.
The Cherry Marketing Institute (CMI) is an organization funded by North American tart cherry growers and processors. CMI's mission is to increase the demand for tart cherries through promotion, market expansion, product development and research. For more information on the science supporting the unique health benefits of cherries and for cherry recipes and menu ideas, visit www.choosecherries.com.
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New research has confirmed that bad habits, such as smoking, drinking, eating fatty foods, and not getting enough exercise, can cut 12 years off of your life.
A team of researchers studied 4,886 British adult men and women for two decades. They observed four different habits to find out which subjects smoked tobacco regularly, drank two (for women) or three (for men) alcoholic beverages daily, failed to complete at least two hours of physical activity weekly, and ate fewer than three combined servings of fruits and vegetables each day.
Of those who participated in the study, 314 participated in each of the bad habits. Twenty-nine percent of them (91) died during the study. Conversely, 387 individuals practiced none of the high-risk behaviors, and only eight-percent (32) of them passed away during the 20 year span. All subjects were at least 18 years of age, with 44 being the average age.
"The combined effect of poor health behaviors on mortality was substantial, indicating that modest, but sustained, improvements to diet and lifestyle could have significant public health benefits," lead author Elisabeth Kvaavik of the
"Developing more efficacious methods by which to promote healthy diets and lifestyles across the population should be an important priority of public health policy," Dr. Kvaavik added.
According to Associated Press (AP) Medical Writer Lindsey Tanner, "The U.S. government generally recommends at least 4 cups of fruits or vegetables daily for adults, depending on age and activity level; and about 2 1/2 hours of exercise weekly… June Stevens, a
The study was published in Monday's edition of the Archives of Internal Medicine.
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This is the chance you have been waiting for! Understand the world in broader ways.
Bring your important questions and let this wise spirit-being share her insights.
Friday June 11, 2010 (7- 9 pm)
The Turfgrass Institute
328 Victoria Road South
(Between College Ave. & York Road)
Cost: $ 20.00
-Lori Wilson, author, social worker, radio show host and internationally recognized intuitive, will be sharing an amazing 2-hour evening that demystifies everything you may have learned or heard about intuition, channeling and tapping into higher wisdom. In her 26 years of developing her extraordinary intuitive abilities, Lori and her ancient Shoshone elder spirit guide, Grandmother, have been teaching thousands to channel higher wisdom and achieve inner trust. Lori believes channeling is not a mystical gift, but rather a skill that everyone can harness for better living.
Join Lori and Grandmother for this evening of channeled ancient wisdom where Grandmother will offer a teaching and then answer audience questions of general interest and benefit to all. Throughout the evening, 5 audience names will be drawn to ask personal questions as well. Get curious and see how paying attention to what seems invisible can change your life!
Come Grow with Us & Bring Your Friends!
TO REGISTER, PLEASE RSVP lori@inneraccess101.com or CALL 519-824-6655.
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For a list of questions from previous presentations, visit www.meetloriwilson.com!
If you have already received this invitation, we regret the overlap in our two mailing lists.